High-voltage, chaotic, and multifocal spikes of hypsarrhythmia are unique to IS.6 This pattern is markedly different from a normal EEG, as shown in these examples:

EEG Chart
EEG Chart

Because hypsarrhythmia plays such an important role in the diagnosis of IS, it's important to capture the pattern when it occurs. A routine EEG may not be sufficient for this purpose; you may wish to order a 24-hour inpatient EEG if you suspect a patient has IS.6

Follow-up EEG in IS: A proposed quality indicator

In 2012, a comprehensive set of quality-of-care indicators for the management of children with IS was developed.9

The proposed indicators can be used to assess and document variations and gaps in quality of care and inform future research and quality improvement interventions. Among these indicators is the practice of a follow-up EEG to confirm cessation of hypsarrhythmia following treatment.9

Helpful Resources

Take the guesswork out of dosing Acthar for IS

From per-injection volume to number of vials, our calculator simplifies the process.

Physician Referral/Prescription Form

Download for your practice to complete.

Reimbursement and co-pay support

Helping you help children with IS get Acthar A.S.A.P.