High-dose, short-duration therapy with Acthar eliminates both spasms and hypsarrhythmia in cryptogenic and symptomatic cases of IS.1-3
Acthar is available as a 5-mL multidose vial containing 80 U/mL (400 U/5-mL vial) that requires no reconstitution or reformulation. Acthar should be dosed as recommended by the FDA: 75 U/m2 twice daily for 2 weeks with a gradual taper of an additional 2 weeks to avoid adrenal insufficiency.1
In the treatment of IS, Acthar is administered by intramuscular injection, which helps ensure IS patients are given the full and correct dose.
The dose of Acthar is typically calculated using the Mosteller formula for determining body surface area (BSA).22
Acthar should never be administered intravenously. Prolonged use of Acthar may produce cataracts, glaucoma, and secondary ocular infections. Monitor for signs and symptoms.
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H.P. Acthar® Gel (repository corticotropin injection) is indicated as monotherapy for the treatment of infantile spasms in infants and children under 2 years of age.
IMPORTANT SAFETY INFORMATIONContraindications