High-dose, short-duration therapy with Acthar eliminates both spasms and hypsarrhythmia in cryptogenic and symptomatic cases of infantile spasms (IS).1-3

Acthar is available as a 5-mL multidose vial containing 80 U/mL (400 U/5-mL vial) that requires no reconstitution or reformulation. For optimal efficacy and safety, Acthar should be dosed as recommended by the FDA: 75 U/m2 twice daily for 2 weeks with a gradual taper of an additional 2 weeks to avoid adrenal insufficiency.1-3,11-16

In the treatment of IS, Acthar is administered by intramuscular injection, which helps ensure IS patients are given the full and correct dose.

The dose of Acthar is typically calculated using the Mosteller formula for determining body surface area (BSA).25


Acthar should never be administered intravenously. Prolonged use of Acthar may produce cataracts, glaucoma, and secondary ocular infections. Monitor for signs and symptoms.

Injection training

When used to treat infantile spasms, Acthar must be injected intramuscularly, as demonstrated to caregivers in the following videos, which are also available on the caregiver site and in the patient education materials.


IM Injection Training: English


IM Injection Training: Spanish

Helpful Resources

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Physician Referral/Prescription Form

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Reimbursement and co-pay support

Helping you help children with IS get Acthar A.S.A.P.